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To this first phase succeeds more or less rapidly erythema, significant of vascular paralysis of sympathetic origin, and then processes of vesiculation and eczematisation, the origin of which, in so far as it relates to the influence of the nerve terminals, is less obvious. Laborde, about the same time, pointed out the predominant action of spartein on the heart of the lower animals, and now, in conjunction with Legris, he gives an account of its physiological In some of the lower animals, according to these observers, spartein causes increased reflex excitability of the spinal cord; in all it strengthens the systolic impulse If three-fifths of a grain be given subcutaneously to a rabbit the heart's beat is strengthened and slowed, and the effect is still "lamberts l arginine 1000 mg" more marked if the injection be repeated; frequent and abundant urination likewise ensues.